About
We are using optimized human enzymes to target the largely unexplored tumor small molecule immune messengers and microenvironment regulators that can be drivers of disease progression
Vision
At Delta TpX we aim to change the lives of cancer patients by genetic targeting of the small molecule immune messenger pathways playing a role in escape from antitumor immunity
Strategy
Enzyme therapeutics provide a highly specific means of blocking small molecule immune messengers that cannot otherwise be effectively achieved with antibody or small molecule antagonists. Our pipeline of engineered human therapeutic enzymes has the potential to chance how
Our Lead Molecule
DTX-5500 is a genetically targeted enzyme replacement therapy for an immunotherapy target found in tumors with deletion or silencing of the methylthioadenosine phosphorylase (MTAP) tumor suppressor gene. Deletion of MTAP at Chromosome 9p21.3 is the second most common tumor suppressor gene deletion in cancer occurring in ~15% of all solid tumors. Loss of MTAP function provides suppresses antitumor immunity through a noncanonical pathway of immunosuppression. In patients MTAP deletion predicts worse survival, an immunosuppressed tumor microenvironment, and resistance to immune checkpoint inhibitor immunotherapy. There is already an FDA approved genetic diagnostic test for MTAP deletion
- MTAP: methylthioadenosine phosphorylase
- MTA: methylthioadenosine
- MTR-1P: methylthioribose 1-phosphate
News
Conference Presentations:
November 2020 Texas Life Science
January 2021 Biotech Showcase
Contact
If you would like to learn more about Delta TPC or have any questions please contact us.